Drug interactions
Creatine + Mefenamic acid
Severity: Minor
Creatine and Mefenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Creatine supplements may raise serum creatinine and have been theoretically linked to renal stress at high doses, while NSAIDs such as mefenamic acid can reduce renal perfusion. Together they might add to renal burden, particularly in dehydration or pre-existing kidney disease. Clinical evidence is lacking.
What this interaction means in plain words
Creatine and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive renal effects; NSAID prostaglandin inhibition reduces renal blood flow, and the nephrotoxic potential of creatine is unproven.
What to do
Monitor serum creatinine in patients with renal risk factors who use both, and keep them well hydrated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Creatine with Mefenamic acid?
MediHelp rates the interaction as minor. Creatine and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Creatine supplements may raise serum creatinine and have been theoretically linked to renal stress at high doses, while NSAIDs such as mefenamic acid can reduce renal perfusion. Together they might add to renal burden, particularly in dehydration or pre-existing kidney disease. Clinical evidence is lacking.
How serious is the interaction between Creatine and Mefenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine in patients with renal risk factors who use both, and keep them well hydrated.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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