Drug interactions
Crizotinib + Dabigatran
Severity: Major
Crizotinib and Dabigatran: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits P-glycoprotein and may increase absorption of dabigatran etexilate, raising dabigatran exposure. This increases bleeding risk, particularly in patients with renal impairment.
What this interaction means in plain words
Crizotinib and Dabigatran can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Crizotinib inhibits intestinal P-gp, increasing dabigatran etexilate absorption and plasma levels.
What to do
Avoid in patients with reduced renal function (per dabigatran labeling thresholds). Otherwise monitor renal function and bleeding, and consider reducing the dabigatran dose or using another anticoagulant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Dabigatran?
MediHelp rates the interaction as major. Crizotinib and Dabigatran can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib inhibits P-glycoprotein and may increase absorption of dabigatran etexilate, raising dabigatran exposure. This increases bleeding risk, particularly in patients with renal impairment.
How serious is the interaction between Crizotinib and Dabigatran?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with reduced renal function (per dabigatran labeling thresholds). Otherwise monitor renal function and bleeding, and consider reducing the dabigatran dose or using another anticoagulant.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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