Drug interactions
Crizotinib + Danazol
Severity: Moderate
Crizotinib and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may modestly raise crizotinib exposure. The aldehyde dehydrogenase mechanism cited is not an established pathway for crizotinib.
What this interaction means in plain words
Crizotinib and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable weak CYP3A4 inhibition by danazol; the stated aldehyde dehydrogenase mechanism is not established.
What to do
Monitor for crizotinib adverse effects such as hepatotoxicity and bradycardia. Reduce the crizotinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Danazol?
MediHelp rates the interaction as moderate. Crizotinib and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak CYP3A4 inhibitor and may modestly raise crizotinib exposure. The aldehyde dehydrogenase mechanism cited is not an established pathway for crizotinib.
How serious is the interaction between Crizotinib and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for crizotinib adverse effects such as hepatotoxicity and bradycardia. Reduce the crizotinib dose if toxicity occurs.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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