Drug interactions
Crizotinib + Dexamethasone-tobramycin
Severity: Moderate
Crizotinib and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may lower crizotinib exposure through CYP3A4 induction, while crizotinib as a CYP3A inhibitor may raise dexamethasone exposure. Net effects on efficacy and corticosteroid adverse effects are possible but are usually modest.
What this interaction means in plain words
Crizotinib and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Bidirectional CYP3A4 effects: dexamethasone induces and crizotinib inhibits CYP3A.
What to do
Monitor for reduced crizotinib response and corticosteroid adverse effects when systemic dexamethasone is used long term. Adjust doses according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Crizotinib and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may lower crizotinib exposure through CYP3A4 induction, while crizotinib as a CYP3A inhibitor may raise dexamethasone exposure. Net effects on efficacy and corticosteroid adverse effects are possible but are usually modest.
How serious is the interaction between Crizotinib and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced crizotinib response and corticosteroid adverse effects when systemic dexamethasone is used long term. Adjust doses according to clinical response.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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