Drug interactions
Crizotinib + Dichlorphenamide
Severity: Moderate
Crizotinib and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes potassium loss, and crizotinib can prolong the QT interval and cause bradycardia. Hypokalemia increases the risk of QT-related arrhythmias.
What this interaction means in plain words
Crizotinib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Dichlorphenamide-induced hypokalemia increases proarrhythmic risk of crizotinib's QT prolongation.
What to do
Monitor serum potassium and ECG, and replace potassium to keep levels in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Crizotinib with Dichlorphenamide?
MediHelp rates the interaction as moderate. Crizotinib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes potassium loss, and crizotinib can prolong the QT interval and cause bradycardia. Hypokalemia increases the risk of QT-related arrhythmias.
How serious is the interaction between Crizotinib and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG, and replace potassium to keep levels in the normal range.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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