Drug interactions
Crizotinib + Estradiol vaginal
Severity: Minor
Crizotinib and Estradiol vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may modestly raise systemic estradiol through CYP3A4 inhibition. With low-dose vaginal estradiol, systemic exposure is small and a clinically meaningful effect is unlikely.
What this interaction means in plain words
Crizotinib and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Crizotinib inhibits CYP3A4, which partly metabolizes estradiol.
What to do
No routine adjustment is needed. Watch for estrogenic adverse effects such as breast tenderness or unexpected bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Estradiol vaginal?
MediHelp rates the interaction as minor. Crizotinib and Estradiol vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib may modestly raise systemic estradiol through CYP3A4 inhibition. With low-dose vaginal estradiol, systemic exposure is small and a clinically meaningful effect is unlikely.
How serious is the interaction between Crizotinib and Estradiol vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for estrogenic adverse effects such as breast tenderness or unexpected bleeding.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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