Drug interactions
Crizotinib + Ethosuximide
Severity: Moderate
Crizotinib and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A inhibitor and may raise levels of ethosuximide, which is partly metabolised by CYP3A4. Higher ethosuximide levels could increase nausea, drowsiness, ataxia and other dose-related effects.
What this interaction means in plain words
Crizotinib and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Ethosuximide belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by crizotinib reduces ethosuximide clearance.
What to do
Monitor for ethosuximide toxicity and consider checking serum levels, reducing the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Ethosuximide?
MediHelp rates the interaction as moderate. Crizotinib and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A inhibitor and may raise levels of ethosuximide, which is partly metabolised by CYP3A4. Higher ethosuximide levels could increase nausea, drowsiness, ataxia and other dose-related effects.
How serious is the interaction between Crizotinib and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide toxicity and consider checking serum levels, reducing the dose if adverse effects occur.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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