Drug interactions
Crizotinib + Flurazepam
Severity: Moderate
Crizotinib and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may raise flurazepam and its active metabolite levels. This may cause excessive sedation, confusion and respiratory depression, especially in older adults.
What this interaction means in plain words
Crizotinib and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Crizotinib inhibits CYP3A4-mediated metabolism of flurazepam.
What to do
Monitor for oversedation and consider a lower flurazepam dose. Consider an alternative hypnotic that is not CYP3A4-dependent, such as temazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Flurazepam?
MediHelp rates the interaction as moderate. Crizotinib and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and may raise flurazepam and its active metabolite levels. This may cause excessive sedation, confusion and respiratory depression, especially in older adults.
How serious is the interaction between Crizotinib and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider a lower flurazepam dose. Consider an alternative hypnotic that is not CYP3A4-dependent, such as temazepam.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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