Drug interactions
Crizotinib + Gemtuzumab
Severity: Moderate
Crizotinib and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both crizotinib and gemtuzumab ozogamicin have been linked to QT prolongation. Using them together may increase the chance of clinically relevant QT prolongation and arrhythmia, particularly in patients with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Crizotinib and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Check ECG and electrolytes at baseline and during treatment, and correct potassium and magnesium deficits. Reduce or stop crizotinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Gemtuzumab?
MediHelp rates the interaction as moderate. Crizotinib and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both crizotinib and gemtuzumab ozogamicin have been linked to QT prolongation. Using them together may increase the chance of clinically relevant QT prolongation and arrhythmia, particularly in patients with electrolyte disturbances or cardiac disease.
How serious is the interaction between Crizotinib and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and during treatment, and correct potassium and magnesium deficits. Reduce or stop crizotinib if QTc becomes markedly prolonged.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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