Drug interactions
Crizotinib + Glecaprevir / pibrentasvir
Severity: Minor
Crizotinib and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits P-glycoprotein, which may raise exposure to glecaprevir and pibrentasvir, both P-gp substrates. The increase is likely small and the antiviral combination is generally well tolerated, so the clinical effect is usually limited.
What this interaction means in plain words
Crizotinib and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by crizotinib, increasing absorption of the antivirals.
What to do
No dose change is usually needed; monitor for hepatic adverse effects and gastrointestinal tolerance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Crizotinib and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib inhibits P-glycoprotein, which may raise exposure to glecaprevir and pibrentasvir, both P-gp substrates. The increase is likely small and the antiviral combination is generally well tolerated, so the clinical effect is usually limited.
How serious is the interaction between Crizotinib and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for hepatic adverse effects and gastrointestinal tolerance.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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