Drug interactions
Crizotinib + Hydroxyprogesterone caproate
Severity: Minor
Crizotinib and Hydroxyprogesterone caproate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A inhibitor and may increase exposure to hydroxyprogesterone caproate, which is partly metabolized by CYP3A. The clinical consequence is probably small and the effect has not been well characterized.
What this interaction means in plain words
Crizotinib and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A-mediated metabolism of hydroxyprogesterone caproate by crizotinib.
What to do
No routine dose adjustment is needed; monitor for progestogenic adverse effects such as fluid retention or mood change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Hydroxyprogesterone caproate?
MediHelp rates the interaction as minor. Crizotinib and Hydroxyprogesterone caproate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib is a moderate CYP3A inhibitor and may increase exposure to hydroxyprogesterone caproate, which is partly metabolized by CYP3A. The clinical consequence is probably small and the effect has not been well characterized.
How serious is the interaction between Crizotinib and Hydroxyprogesterone caproate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; monitor for progestogenic adverse effects such as fluid retention or mood change.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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