Drug interactions
Crizotinib + Ibuprofen / famotidine
Severity: Minor
Crizotinib and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine reduces gastric acidity, and crizotinib solubility is pH dependent, so absorption could theoretically fall. The effect has not been shown to be clinically significant, and ibuprofen is not expected to contribute.
What this interaction means in plain words
Crizotinib and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced gastric acidity from famotidine may decrease crizotinib dissolution and absorption.
What to do
No routine adjustment is needed; monitor tumor response if acid suppression is long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Crizotinib and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine reduces gastric acidity, and crizotinib solubility is pH dependent, so absorption could theoretically fall. The effect has not been shown to be clinically significant, and ibuprofen is not expected to contribute.
How serious is the interaction between Crizotinib and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor tumor response if acid suppression is long term.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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