Drug interactions
Crizotinib + Indapamide
Severity: Major
Crizotinib and Indapamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, and indapamide-related hypokalemia or hypomagnesemia increases the risk of torsades de pointes. Combining them increases proarrhythmic risk.
What this interaction means in plain words
Crizotinib and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with electrolyte depletion from indapamide as a contributing factor.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes periodically. Correct potassium and magnesium, and consider an alternative antihypertensive if QT prolongation develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Indapamide?
MediHelp rates the interaction as major. Crizotinib and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib can prolong the QT interval and cause bradycardia, and indapamide-related hypokalemia or hypomagnesemia increases the risk of torsades de pointes. Combining them increases proarrhythmic risk.
How serious is the interaction between Crizotinib and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes periodically. Correct potassium and magnesium, and consider an alternative antihypertensive if QT prolongation develops.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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