Drug interactions
Crizotinib + Indinavir
Severity: Major
Crizotinib and Indinavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A inhibitor and can substantially increase crizotinib exposure, raising the risk of QT prolongation, hepatotoxicity and other toxicity. Crizotinib may also modestly raise indinavir levels via P-gp inhibition.
What this interaction means in plain words
Crizotinib and Indinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong CYP3A4 inhibition by indinavir reduces crizotinib clearance; crizotinib may inhibit P-gp efflux of indinavir.
What to do
Avoid the combination; if unavoidable, reduce the crizotinib dose per labeling and monitor ECG, liver tests and indinavir toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Indinavir?
MediHelp rates the interaction as major. Crizotinib and Indinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir is a strong CYP3A inhibitor and can substantially increase crizotinib exposure, raising the risk of QT prolongation, hepatotoxicity and other toxicity. Crizotinib may also modestly raise indinavir levels via P-gp inhibition.
How serious is the interaction between Crizotinib and Indinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if unavoidable, reduce the crizotinib dose per labeling and monitor ECG, liver tests and indinavir toxicity.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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