Drug interactions
Crizotinib + Irinotecan liposomal
Severity: Major
Crizotinib and Irinotecan liposomal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may inhibit CYP3A4-mediated metabolism of irinotecan, increasing exposure to irinotecan and its active metabolite SN-38. This may worsen neutropenia and diarrhea.
What this interaction means in plain words
Crizotinib and Irinotecan liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Crizotinib inhibition of CYP3A4 reduces irinotecan clearance.
What to do
Avoid if possible; otherwise monitor blood counts and diarrhea closely and reduce irinotecan if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Irinotecan liposomal?
MediHelp rates the interaction as major. Crizotinib and Irinotecan liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib may inhibit CYP3A4-mediated metabolism of irinotecan, increasing exposure to irinotecan and its active metabolite SN-38. This may worsen neutropenia and diarrhea.
How serious is the interaction between Crizotinib and Irinotecan liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor blood counts and diarrhea closely and reduce irinotecan if toxicity develops.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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