Drug interactions
Crizotinib + Isoniazid
Severity: Moderate
Crizotinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is metabolized by CYP3A4 and isoniazid can inhibit this enzyme to a modest degree. Crizotinib exposure may rise, increasing risks of hepatotoxicity, QT prolongation and bradycardia. Both drugs are also hepatotoxic, which adds to liver risk.
What this interaction means in plain words
Crizotinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, reducing crizotinib clearance, together with additive hepatotoxic potential.
What to do
Monitor liver enzymes, ECG and heart rate regularly during co-administration. Reduce the crizotinib dose if hepatic or cardiac toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Isoniazid?
MediHelp rates the interaction as moderate. Crizotinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is metabolized by CYP3A4 and isoniazid can inhibit this enzyme to a modest degree. Crizotinib exposure may rise, increasing risks of hepatotoxicity, QT prolongation and bradycardia. Both drugs are also hepatotoxic, which adds to liver risk.
How serious is the interaction between Crizotinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, ECG and heart rate regularly during co-administration. Reduce the crizotinib dose if hepatic or cardiac toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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