Drug interactions
Crizotinib + Isradipine
Severity: Moderate
Crizotinib and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A and may increase isradipine exposure, causing hypotension, edema or reflex tachycardia. Crizotinib also causes bradycardia and QT prolongation, so cardiovascular effects may be additive.
What this interaction means in plain words
Crizotinib and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by crizotinib reduces isradipine metabolism, with additive cardiovascular effects.
What to do
Monitor blood pressure and heart rate and obtain ECG as needed. Reduce the isradipine dose if hypotension or marked bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Isradipine?
MediHelp rates the interaction as moderate. Crizotinib and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A and may increase isradipine exposure, causing hypotension, edema or reflex tachycardia. Crizotinib also causes bradycardia and QT prolongation, so cardiovascular effects may be additive.
How serious is the interaction between Crizotinib and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and obtain ECG as needed. Reduce the isradipine dose if hypotension or marked bradycardia develops.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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