Drug interactions
Crizotinib + Lumefantrine
Severity: Major
Crizotinib and Lumefantrine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine, given with artemether, prolongs the QT interval, and crizotinib has the same effect. Combined use increases the risk of torsades de pointes.
What this interaction means in plain words
Crizotinib and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation; lumefantrine is also a CYP3A4 substrate that crizotinib may inhibit.
What to do
Avoid if possible, or hold crizotinib during the antimalarial course. If co-administered, obtain ECG and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Lumefantrine?
MediHelp rates the interaction as major. Crizotinib and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumefantrine, given with artemether, prolongs the QT interval, and crizotinib has the same effect. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Crizotinib and Lumefantrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or hold crizotinib during the antimalarial course. If co-administered, obtain ECG and correct electrolytes.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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