Drug interactions
Crizotinib + Metformin-sitagliptin
Severity: Minor
Crizotinib and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may increase sitagliptin exposure by inhibiting its efflux. Higher sitagliptin levels could increase adverse effects, though sitagliptin has a wide safety margin.
What this interaction means in plain words
Crizotinib and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein by crizotinib reduces sitagliptin efflux; crizotinib may also inhibit OCT1/OCT2 affecting metformin.
What to do
Monitor glucose and tolerability. No routine dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Crizotinib and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib may increase sitagliptin exposure by inhibiting its efflux. Higher sitagliptin levels could increase adverse effects, though sitagliptin has a wide safety margin.
How serious is the interaction between Crizotinib and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and tolerability. No routine dose change is usually needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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