Drug interactions
Crizotinib + Methylergonovine
Severity: Major
Crizotinib and Methylergonovine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may raise methylergonovine concentrations through CYP3A inhibition. Elevated ergot levels risk vasospasm and ischemia, a serious problem with strong CYP3A inhibitors, though crizotinib is only a moderate inhibitor.
What this interaction means in plain words
Crizotinib and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by crizotinib decreases methylergonovine metabolism, increasing ergot exposure.
What to do
Avoid the combination where possible and choose an alternative uterotonic. If used, monitor for peripheral ischemia, paresthesia and severe hypertension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Methylergonovine?
MediHelp rates the interaction as major. Crizotinib and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib may raise methylergonovine concentrations through CYP3A inhibition. Elevated ergot levels risk vasospasm and ischemia, a serious problem with strong CYP3A inhibitors, though crizotinib is only a moderate inhibitor.
How serious is the interaction between Crizotinib and Methylergonovine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative uterotonic. If used, monitor for peripheral ischemia, paresthesia and severe hypertension.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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