Drug interactions
Crizotinib + Nafcillin
Severity: Moderate
Crizotinib and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower crizotinib concentrations, risking reduced efficacy. The effect is usually limited to the antibiotic course but can persist briefly afterward.
What this interaction means in plain words
Crizotinib and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by nafcillin increases crizotinib metabolism.
What to do
Use a non-inducing antibiotic such as a cephalosporin where appropriate. If nafcillin is needed, monitor for reduced crizotinib response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Nafcillin?
MediHelp rates the interaction as moderate. Crizotinib and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin induces CYP3A4 and may lower crizotinib concentrations, risking reduced efficacy. The effect is usually limited to the antibiotic course but can persist briefly afterward.
How serious is the interaction between Crizotinib and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antibiotic such as a cephalosporin where appropriate. If nafcillin is needed, monitor for reduced crizotinib response.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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