Drug interactions
Crizotinib + Olaparib
Severity: Moderate
Crizotinib and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is cleared mainly by CYP3A, and crizotinib may raise its exposure. This can increase myelosuppression such as anemia and neutropenia.
What this interaction means in plain words
Crizotinib and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of olaparib.
What to do
If unavoidable, reduce olaparib to the labeled dose for moderate CYP3A inhibitors. Monitor blood counts regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Crizotinib with Olaparib?
MediHelp rates the interaction as moderate. Crizotinib and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib is cleared mainly by CYP3A, and crizotinib may raise its exposure. This can increase myelosuppression such as anemia and neutropenia.
How serious is the interaction between Crizotinib and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, reduce olaparib to the labeled dose for moderate CYP3A inhibitors. Monitor blood counts regularly.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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