Drug interactions
Crizotinib + Olodaterol inhaled
Severity: Moderate
Crizotinib and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval, and long-acting beta-2 agonists such as olodaterol may also affect cardiac repolarization and lower potassium. Combined use may modestly increase arrhythmia risk, particularly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Crizotinib and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT-prolonging effects, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Obtain a baseline ECG and monitor ECG and potassium and magnesium periodically; correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Crizotinib and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval, and long-acting beta-2 agonists such as olodaterol may also affect cardiac repolarization and lower potassium. Combined use may modestly increase arrhythmia risk, particularly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Crizotinib and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and potassium and magnesium periodically; correct electrolyte abnormalities.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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