Drug interactions
Crizotinib + Paclitaxel protein bound
Severity: Moderate
Crizotinib and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and P-glycoprotein, and paclitaxel is metabolized by CYP2C8 and CYP3A4 and is a P-gp substrate. Exposure to paclitaxel may rise, increasing myelosuppression and neuropathy.
What this interaction means in plain words
Crizotinib and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Crizotinib inhibits CYP3A4 and P-glycoprotein, reducing paclitaxel clearance.
What to do
Monitor blood counts and signs of neuropathy, and reduce the paclitaxel dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Crizotinib and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and P-glycoprotein, and paclitaxel is metabolized by CYP2C8 and CYP3A4 and is a P-gp substrate. Exposure to paclitaxel may rise, increasing myelosuppression and neuropathy.
How serious is the interaction between Crizotinib and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy, and reduce the paclitaxel dose if toxicity occurs.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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