Drug interactions
Crizotinib + Protriptyline
Severity: Moderate
Crizotinib and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both crizotinib and the tricyclic antidepressant protriptyline can prolong the QT interval. Combined use may raise the risk of ventricular arrhythmias, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Crizotinib and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Obtain a baseline ECG, monitor ECG and electrolytes during treatment, and consider an antidepressant with less QT effect in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Protriptyline?
MediHelp rates the interaction as moderate. Crizotinib and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both crizotinib and the tricyclic antidepressant protriptyline can prolong the QT interval. Combined use may raise the risk of ventricular arrhythmias, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Crizotinib and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, monitor ECG and electrolytes during treatment, and consider an antidepressant with less QT effect in high-risk patients.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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