Drug interactions
Crizotinib + Rabeprazole
Severity: Moderate
Crizotinib and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib solubility falls at higher pH, so acid suppression could reduce its absorption. No formal study confirms a clinically significant effect.
What this interaction means in plain words
Crizotinib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH may decrease crizotinib solubility and bioavailability.
What to do
Avoid unnecessary PPI use; if acid suppression is needed, monitor tumor response and consider alternative agents such as short-acting antacids spaced from crizotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Rabeprazole?
MediHelp rates the interaction as moderate. Crizotinib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib solubility falls at higher pH, so acid suppression could reduce its absorption. No formal study confirms a clinically significant effect.
How serious is the interaction between Crizotinib and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary PPI use; if acid suppression is needed, monitor tumor response and consider alternative agents such as short-acting antacids spaced from crizotinib.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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