Drug interactions
Crizotinib + Selumetinib
Severity: Moderate
Crizotinib and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib is metabolized mainly by CYP3A4, and crizotinib may increase its exposure. This may increase adverse effects such as gastrointestinal toxicity, rash and cardiomyopathy.
What this interaction means in plain words
Crizotinib and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Selumetinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of selumetinib.
What to do
If unavoidable, reduce the selumetinib dose per labeling for moderate CYP3A inhibitors. Monitor tolerability and resume the previous dose after crizotinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Crizotinib with Selumetinib?
MediHelp rates the interaction as moderate. Crizotinib and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib is metabolized mainly by CYP3A4, and crizotinib may increase its exposure. This may increase adverse effects such as gastrointestinal toxicity, rash and cardiomyopathy.
How serious is the interaction between Crizotinib and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, reduce the selumetinib dose per labeling for moderate CYP3A inhibitors. Monitor tolerability and resume the previous dose after crizotinib is stopped.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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