Drug interactions
Crizotinib + Sodium bicarbonate
Severity: Minor
Crizotinib and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raising gastric pH could reduce the solubility of crizotinib, which is more soluble in acidic conditions. A clinically meaningful effect has not been established and is likely small.
What this interaction means in plain words
Crizotinib and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH may reduce crizotinib dissolution and absorption.
What to do
Separating doses by a couple of hours is reasonable; no dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Crizotinib with Sodium bicarbonate?
MediHelp rates the interaction as minor. Crizotinib and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Raising gastric pH could reduce the solubility of crizotinib, which is more soluble in acidic conditions. A clinically meaningful effect has not been established and is likely small.
How serious is the interaction between Crizotinib and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separating doses by a couple of hours is reasonable; no dose change is required.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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