Drug interactions
Crizotinib + Teniposide
Severity: Moderate
Crizotinib and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and P-glycoprotein, both of which contribute to teniposide clearance and disposition. Teniposide exposure may rise, increasing myelosuppression, mucositis and hypersensitivity risk.
What this interaction means in plain words
Crizotinib and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Crizotinib inhibits CYP3A4-mediated metabolism and P-glycoprotein efflux of teniposide.
What to do
Monitor blood counts and signs of teniposide toxicity closely, and consider reducing the teniposide dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Teniposide?
MediHelp rates the interaction as moderate. Crizotinib and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and P-glycoprotein, both of which contribute to teniposide clearance and disposition. Teniposide exposure may rise, increasing myelosuppression, mucositis and hypersensitivity risk.
How serious is the interaction between Crizotinib and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of teniposide toxicity closely, and consider reducing the teniposide dose if toxicity appears.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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