Drug interactions
Crizotinib + Tezacaftor
Severity: Moderate
Crizotinib and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A moderately and can raise tezacaftor exposure. Higher tezacaftor levels may increase the risk of dose-related adverse effects such as liver enzyme elevations.
What this interaction means in plain words
Crizotinib and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Crizotinib inhibits CYP3A4, reducing the metabolism of tezacaftor, a CYP3A substrate.
What to do
Follow the tezacaftor/ivacaftor labeling for moderate CYP3A inhibitors, which calls for a reduced dosing schedule. Monitor liver function tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Crizotinib and Tezacaftor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Tezacaftor?
MediHelp rates the interaction as moderate. Crizotinib and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A moderately and can raise tezacaftor exposure. Higher tezacaftor levels may increase the risk of dose-related adverse effects such as liver enzyme elevations.
How serious is the interaction between Crizotinib and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow the tezacaftor/ivacaftor labeling for moderate CYP3A inhibitors, which calls for a reduced dosing schedule. Monitor liver function tests.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
