Drug interactions
Crizotinib + Tiagabine
Severity: Moderate
Crizotinib and Tiagabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tiagabine is cleared mainly by CYP3A4, which crizotinib inhibits. Tiagabine levels may increase, leading to dizziness, somnolence, tremor, confusion or seizures.
What this interaction means in plain words
Crizotinib and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Crizotinib inhibits CYP3A4, reducing tiagabine metabolism.
What to do
Monitor for CNS adverse effects and seizure control, and lower the tiagabine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Tiagabine?
MediHelp rates the interaction as moderate. Crizotinib and Tiagabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tiagabine is cleared mainly by CYP3A4, which crizotinib inhibits. Tiagabine levels may increase, leading to dizziness, somnolence, tremor, confusion or seizures.
How serious is the interaction between Crizotinib and Tiagabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS adverse effects and seizure control, and lower the tiagabine dose if toxicity occurs.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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