Drug interactions
Crizotinib + Tofacitinib
Severity: Moderate
Crizotinib and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may increase tofacitinib exposure. This raises the risk of dose-related adverse effects such as infection and cytopenias.
What this interaction means in plain words
Crizotinib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated tofacitinib metabolism by crizotinib.
What to do
Monitor for infection and hematologic toxicity; reduce the tofacitinib dose if a potent CYP2C19 inhibitor is also given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Tofacitinib?
MediHelp rates the interaction as moderate. Crizotinib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and may increase tofacitinib exposure. This raises the risk of dose-related adverse effects such as infection and cytopenias.
How serious is the interaction between Crizotinib and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and hematologic toxicity; reduce the tofacitinib dose if a potent CYP2C19 inhibitor is also given.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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