Drug interactions
Crizotinib + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Crizotinib and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib prolongs the QT interval, and vilanterol, a beta-agonist, may add to cardiovascular effects and QT risk. Systemic exposure from inhaled vilanterol is low, so clinical risk is limited but real in susceptible patients.
What this interaction means in plain words
Crizotinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and beta-adrenergic cardiovascular stimulation.
What to do
Monitor ECG and heart rate, correct hypokalemia, and avoid exceeding recommended inhaler doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Crizotinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib prolongs the QT interval, and vilanterol, a beta-agonist, may add to cardiovascular effects and QT risk. Systemic exposure from inhaled vilanterol is low, so clinical risk is limited but real in susceptible patients.
How serious is the interaction between Crizotinib and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, correct hypokalemia, and avoid exceeding recommended inhaler doses.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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