Drug interactions
Crizotinib + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Crizotinib and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and vilanterol may potentiate cardiovascular effects, so arrhythmia risk could increase. Crizotinib's CYP3A4 inhibition may also raise fluticasone exposure slightly. Systemic vilanterol exposure from inhalation is low.
What this interaction means in plain words
Crizotinib and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and beta-adrenergic stimulation, plus possible CYP3A4 inhibition of fluticasone clearance.
What to do
Monitor ECG and heart rate, correct electrolytes, and watch for corticosteroid systemic effects with prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Crizotinib and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval and vilanterol may potentiate cardiovascular effects, so arrhythmia risk could increase. Crizotinib's CYP3A4 inhibition may also raise fluticasone exposure slightly. Systemic vilanterol exposure from inhalation is low.
How serious is the interaction between Crizotinib and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, correct electrolytes, and watch for corticosteroid systemic effects with prolonged use.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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