Drug interactions
Crizotinib + Vincristine liposomal
Severity: Moderate
Crizotinib and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is a substrate of CYP3A4 and P-glycoprotein, both inhibited by crizotinib. Higher vincristine exposure may worsen neurotoxicity, constipation or ileus.
What this interaction means in plain words
Crizotinib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Crizotinib inhibits CYP3A4 and P-glycoprotein, reducing vincristine elimination.
What to do
Monitor for neuropathy and constipation, and consider reducing the vincristine dose if neurotoxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Vincristine liposomal?
MediHelp rates the interaction as moderate. Crizotinib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine is a substrate of CYP3A4 and P-glycoprotein, both inhibited by crizotinib. Higher vincristine exposure may worsen neurotoxicity, constipation or ileus.
How serious is the interaction between Crizotinib and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy and constipation, and consider reducing the vincristine dose if neurotoxicity appears.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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