Drug interactions
Crizotinib + Zanubrutinib
Severity: Moderate
Crizotinib and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib, a moderate CYP3A inhibitor, can increase zanubrutinib exposure. This may increase the risk of hematologic toxicity, infection and bleeding.
What this interaction means in plain words
Crizotinib and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Zanubrutinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing the first-pass and systemic metabolism of zanubrutinib.
What to do
Reduce the zanubrutinib dose to 80 mg twice daily during coadministration, per labeling. Monitor blood counts and for bleeding, and resume the usual dose after crizotinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Crizotinib with Zanubrutinib?
MediHelp rates the interaction as moderate. Crizotinib and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib, a moderate CYP3A inhibitor, can increase zanubrutinib exposure. This may increase the risk of hematologic toxicity, infection and bleeding.
How serious is the interaction between Crizotinib and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the zanubrutinib dose to 80 mg twice daily during coadministration, per labeling. Monitor blood counts and for bleeding, and resume the usual dose after crizotinib is stopped.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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