Drug interactions
Crizotinib + Zolpidem
Severity: Moderate
Crizotinib and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may raise zolpidem concentrations, increasing sedation, confusion and next-day impairment. The magnitude is not well characterized for this pair.
What this interaction means in plain words
Crizotinib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Crizotinib inhibits CYP3A4, reducing the metabolism of zolpidem, which is a CYP3A4 substrate.
What to do
Start with a low zolpidem dose (such as 5 mg) and monitor for excess sedation. Reduce the dose or stop it if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Zolpidem?
MediHelp rates the interaction as moderate. Crizotinib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and may raise zolpidem concentrations, increasing sedation, confusion and next-day impairment. The magnitude is not well characterized for this pair.
How serious is the interaction between Crizotinib and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low zolpidem dose (such as 5 mg) and monitor for excess sedation. Reduce the dose or stop it if impairment occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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