Drug interactions
Cyanocobalamin + Dapagliflozin-metformin
Severity: Minor
Cyanocobalamin and Dapagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term metformin therapy is associated with lower serum vitamin B12 levels and can lead to deficiency, sometimes with anemia or neuropathy. Cyanocobalamin supplementation corrects the deficit and the supplement itself does not impair metformin.
What this interaction means in plain words
Cyanocobalamin and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Metformin impairs calcium-dependent ileal absorption of the vitamin B12-intrinsic factor complex.
What to do
Check serum B12 periodically in patients on long-term metformin, especially with anemia or neuropathy, and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Dapagliflozin-metformin?
MediHelp rates the interaction as minor. Cyanocobalamin and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term metformin therapy is associated with lower serum vitamin B12 levels and can lead to deficiency, sometimes with anemia or neuropathy. Cyanocobalamin supplementation corrects the deficit and the supplement itself does not impair metformin.
How serious is the interaction between Cyanocobalamin and Dapagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum B12 periodically in patients on long-term metformin, especially with anemia or neuropathy, and supplement if low.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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