Drug interactions
Cyanocobalamin + Dexlansoprazole
Severity: Minor
Cyanocobalamin and Dexlansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gastric acid is needed to release vitamin B12 from dietary protein, and long-term acid suppression can contribute to B12 deficiency. Crystalline oral cyanocobalamin is less dependent on acid, so the effect is smaller with supplements.
What this interaction means in plain words
Cyanocobalamin and Dexlansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acid impairs release and absorption of protein-bound vitamin B12.
What to do
Check B12 status periodically in long-term PPI users, especially elderly patients or those with risk factors, and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Dexlansoprazole?
MediHelp rates the interaction as minor. Cyanocobalamin and Dexlansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gastric acid is needed to release vitamin B12 from dietary protein, and long-term acid suppression can contribute to B12 deficiency. Crystalline oral cyanocobalamin is less dependent on acid, so the effect is smaller with supplements.
How serious is the interaction between Cyanocobalamin and Dexlansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check B12 status periodically in long-term PPI users, especially elderly patients or those with risk factors, and supplement if low.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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