Drug interactions
Cyanocobalamin + Famotidine
Severity: Minor
Cyanocobalamin and Famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term acid suppression can reduce absorption of dietary protein-bound vitamin B12. Deficiency may develop over months to years.
What this interaction means in plain words
Cyanocobalamin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acid impairs release of vitamin B12 from food protein, decreasing absorption.
What to do
Monitor vitamin B12 status in patients on prolonged therapy and supplement if levels are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyanocobalamin and Famotidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Famotidine
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Famotidine?
MediHelp rates the interaction as minor. Cyanocobalamin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term acid suppression can reduce absorption of dietary protein-bound vitamin B12. Deficiency may develop over months to years.
How serious is the interaction between Cyanocobalamin and Famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vitamin B12 status in patients on prolonged therapy and supplement if levels are low.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
