Drug interactions
Cyanocobalamin + Mesalamine
Severity: Minor
Cyanocobalamin and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine has been reported to reduce vitamin B12 absorption in a few cases, but evidence is weak. Inflammatory bowel disease itself can also affect B12 status, so it is difficult to attribute any change to mesalamine.
What this interaction means in plain words
Cyanocobalamin and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Possible interference with intestinal absorption of vitamin B12; mechanism not well established.
What to do
No change is needed. Check vitamin B12 levels periodically in patients with extensive ileal disease or long-term therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Mesalamine?
MediHelp rates the interaction as minor. Cyanocobalamin and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mesalamine has been reported to reduce vitamin B12 absorption in a few cases, but evidence is weak. Inflammatory bowel disease itself can also affect B12 status, so it is difficult to attribute any change to mesalamine.
How serious is the interaction between Cyanocobalamin and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed. Check vitamin B12 levels periodically in patients with extensive ileal disease or long-term therapy.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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