Drug interactions
Cyanocobalamin + Neomycin
Severity: Minor
Cyanocobalamin and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin can impair intestinal absorption of vitamin B12, and prolonged use may lower serum cobalamin. This matters mainly with long-term neomycin therapy or in patients with marginal B12 stores.
What this interaction means in plain words
Cyanocobalamin and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Neomycin belongs to Anti Bacterial.
Why it happens
Neomycin causes mucosal injury in the small intestine and may bind bile acids, which reduces absorption of oral cobalamin.
What to do
With prolonged neomycin therapy, monitor serum B12 and give parenteral cyanocobalamin if deficiency develops. Short courses need no action.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Neomycin?
MediHelp rates the interaction as minor. Cyanocobalamin and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin can impair intestinal absorption of vitamin B12, and prolonged use may lower serum cobalamin. This matters mainly with long-term neomycin therapy or in patients with marginal B12 stores.
How serious is the interaction between Cyanocobalamin and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With prolonged neomycin therapy, monitor serum B12 and give parenteral cyanocobalamin if deficiency develops. Short courses need no action.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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