Drug interactions
Cyanocobalamin + Sulphasalazine
Severity: Minor
Cyanocobalamin and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not an established cause of vitamin B12 malabsorption, though it clearly impairs folate absorption. Any effect on oral cyanocobalamin is probably small.
What this interaction means in plain words
Cyanocobalamin and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Possible reduced intestinal absorption; mechanism not well established.
What to do
No routine action. Check B12 levels if macrocytosis or neuropathy develops in long-term therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Sulphasalazine?
MediHelp rates the interaction as minor. Cyanocobalamin and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not an established cause of vitamin B12 malabsorption, though it clearly impairs folate absorption. Any effect on oral cyanocobalamin is probably small.
How serious is the interaction between Cyanocobalamin and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action. Check B12 levels if macrocytosis or neuropathy develops in long-term therapy.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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