Drug interactions
Cyclizine + Diazepam
Severity: Moderate
Cyclizine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic properties, and in combination with diazepam it can increase drowsiness and impair concentration. The effect is usually manageable but is relevant for driving and older patients.
What this interaction means in plain words
Cyclizine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from central H1 antagonism and GABA-A potentiation.
What to do
Monitor for oversedation and counsel on driving and alcohol. Consider a less sedating antiemetic where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Diazepam?
MediHelp rates the interaction as moderate. Cyclizine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic properties, and in combination with diazepam it can increase drowsiness and impair concentration. The effect is usually manageable but is relevant for driving and older patients.
How serious is the interaction between Cyclizine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and counsel on driving and alcohol. Consider a less sedating antiemetic where appropriate.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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