Drug interactions
Cyclizine + Dimenhydrinate
Severity: Moderate
Cyclizine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating antiemetic antihistamines with anticholinergic activity. Combined use duplicates therapy and increases drowsiness, dry mouth, blurred vision and confusion.
What this interaction means in plain words
Cyclizine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive H1-receptor antagonism and muscarinic blockade.
What to do
Avoid concurrent use and keep to a single antihistamine antiemetic. Monitor older patients for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Cyclizine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating antiemetic antihistamines with anticholinergic activity. Combined use duplicates therapy and increases drowsiness, dry mouth, blurred vision and confusion.
How serious is the interaction between Cyclizine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep to a single antihistamine antiemetic. Monitor older patients for sedation and anticholinergic effects.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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