Drug interactions
Cyclizine + Dosulepin
Severity: Moderate
Cyclizine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with marked sedative and anticholinergic effects, which cyclizine adds to. The combination can cause heavy sedation, dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Cyclizine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Dosulepin belongs to Central Nervous System.
Why it happens
Additive H1-antihistaminic and antimuscarinic effects.
What to do
Choose a less anticholinergic antiemetic where possible, such as one from a different class. If combined, monitor for anticholinergic toxicity and oversedation, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Cyclizine with Dosulepin?
MediHelp rates the interaction as moderate. Cyclizine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with marked sedative and anticholinergic effects, which cyclizine adds to. The combination can cause heavy sedation, dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Cyclizine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a less anticholinergic antiemetic where possible, such as one from a different class. If combined, monitor for anticholinergic toxicity and oversedation, particularly in older patients.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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