Drug interactions
Cyclizine + Doxylamine
Severity: Moderate
Cyclizine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating first-generation antihistamines with anticholinergic properties. Taking them together increases drowsiness, impaired alertness and anticholinergic adverse effects.
What this interaction means in plain words
Cyclizine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Doxylamine belongs to Respiratory.
Why it happens
Additive central H1-receptor blockade and muscarinic antagonism.
What to do
Avoid duplicate sedating antihistamines. Counsel against driving and monitor older patients for confusion and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Doxylamine
Frequently asked questions
Can I take Cyclizine with Doxylamine?
MediHelp rates the interaction as moderate. Cyclizine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating first-generation antihistamines with anticholinergic properties. Taking them together increases drowsiness, impaired alertness and anticholinergic adverse effects.
How serious is the interaction between Cyclizine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate sedating antihistamines. Counsel against driving and monitor older patients for confusion and urinary retention.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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