Drug interactions
Cyclizine + Fesoterodine
Severity: Moderate
Cyclizine and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has antimuscarinic activity that adds to that of fesoterodine. This can increase dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
What this interaction means in plain words
Cyclizine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Fesoterodine belongs to Genitourinary.
Why it happens
Additive anticholinergic effects at muscarinic receptors.
What to do
Monitor for anticholinergic adverse effects and limit the duration of cyclizine; choose a non-anticholinergic antiemetic in frail or elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Fesoterodine?
MediHelp rates the interaction as moderate. Cyclizine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has antimuscarinic activity that adds to that of fesoterodine. This can increase dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older patients.
How serious is the interaction between Cyclizine and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and limit the duration of cyclizine; choose a non-anticholinergic antiemetic in frail or elderly patients.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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