Drug interactions
Cyclizine + Hyaluronidase
Severity: Minor
Cyclizine and Hyaluronidase: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labeling for hyaluronidase notes that antihistamines in large systemic doses may make tissues partly resistant to its spreading action. A reduced dispersion effect may occur, with larger hyaluronidase amounts needed for the same result.
What this interaction means in plain words
Cyclizine and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclizine belongs to Respiratory; Hyaluronidase belongs to Miscellaneous.
Why it happens
Antihistamines are reported to reduce tissue responsiveness to hyaluronidase; the exact mechanism is not well established.
What to do
Monitor the dispersion effect of hyaluronidase and titrate the dose to response in patients on high-dose cyclizine. No pre-emptive change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Cyclizine with Hyaluronidase?
MediHelp rates the interaction as minor. Cyclizine and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labeling for hyaluronidase notes that antihistamines in large systemic doses may make tissues partly resistant to its spreading action. A reduced dispersion effect may occur, with larger hyaluronidase amounts needed for the same result.
How serious is the interaction between Cyclizine and Hyaluronidase?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the dispersion effect of hyaluronidase and titrate the dose to response in patients on high-dose cyclizine. No pre-emptive change is usually needed.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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