Drug interactions
Cyclizine + Neostigmine
Severity: Minor
Cyclizine and Neostigmine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic activity that opposes the effect of neostigmine. Reduced efficacy of neostigmine, for example in reversal of neuromuscular block or myasthenia treatment, is possible.
What this interaction means in plain words
Cyclizine and Neostigmine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclizine belongs to Respiratory; Neostigmine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between cholinesterase inhibition and muscarinic receptor blockade.
What to do
Monitor response to neostigmine in patients receiving cyclizine and consider a non-anticholinergic antiemetic if effect is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclizine and Neostigmine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Neostigmine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Neostigmine?
MediHelp rates the interaction as minor. Cyclizine and Neostigmine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclizine has anticholinergic activity that opposes the effect of neostigmine. Reduced efficacy of neostigmine, for example in reversal of neuromuscular block or myasthenia treatment, is possible.
How serious is the interaction between Cyclizine and Neostigmine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to neostigmine in patients receiving cyclizine and consider a non-anticholinergic antiemetic if effect is lost.
What other medicines interact with Neostigmine?
MediHelp also lists interactions of Neostigmine with, for example, Huperzine a, Physostigmine, Pyridostigmine. The full list is on the Neostigmine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
